Publications

Year: 2024

• Saini, M., Gaurav, A., Hussain, A., & Pathania, R. (2024). Small Molecule IITR08367 Potentiates Antibacterial Efficacy of Fosfomycin against Acinetobacter baumannii by Efflux Pump Inhibition. ACS Infectious Diseases. *Published along with cover art* [PMID: 38562022]

Year: 2023

• Saini, M., Gaurav, A., Kothari, A., Omar, B. J., Gupta, V., Bhattacharjee, A., & Pathania, R. "Small Molecule IITR00693 (2-Aminoperimidine) Synergizes Polymyxin B Activity against Staphylococcus aureus and Pseudomonas aeruginosa". ACS Infectious Diseases, (2023) 9(3), 692-705. *Published along with cover art* [PMID: 36716174]

• Gupta, R., Singh, M., & Pathania, R. (2023). "Chemical genetic approaches for the discovery of bacterial cell wall inhibitors". RSC Medicinal Chemistry. *Published along with cover art* [PMID: PMC10650376]

• Gaurav, A., Bakht, P., Saini, M., Pandey, S., & Pathania, R. (2023). "Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors". Microbiology, 169(5), 001333. [PMID: PMC10268834]

• Shadan, A., Pathak, A., Ma, Y., Pathania, R., & Singh, R. P. "Deciphering the virulence factors, regulation, and immune response to Acinetobacter baumannii infection" (2023). Frontiers in Cellular and Infection Microbiology, 13, 156. [PMID: PMC10038080] 

Year: 2022

• Dubey, V., Devnath, K., Gupta, V. K., Kalyan, G., Singh, M., Kothari, A., ... & Pathania, R. "Disulfiram enhances meropenem activity against NDM-and IMP-producing carbapenem-resistant Acinetobacter baumannii infections". Journal of Antimicrobial Chemotherapy (2022): 77(5), 1313-1323. [PMID: 35199158]

• Kumar, P., Shaikh, A. A., Kumar, P., Gupta, V. K., Dhyani, R., Sharma, T. K., ... Pathania, R. & Navani, N. K. (2022). "Double-Edged Nanobiotic Platform with Protean Functionality: Leveraging the Synergistic Antibacterial Activity of a Food-Grade Peptide to Mitigate Multidrug-Resistant Bacterial Pathogens". ACS Applied Materials & Interfaces. [PMID: 35486715] 

Year: 2021

• Gaurav, A., Gupta, V., Shrivastava, S. K., & Pathania, R. "Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli". Communications biology (2021): 4(1), 1-12. [PMID: PMC8110569] 

• Dubey, V., Gupta, R., & Pathania, R. (2021). "Targeting superoxide dismutase confers enhanced reactive oxygen species-mediated eradication of polymyxin B-induced Acinetobacter baumannii persisters. Antimicrobial Agents and Chemotherapy, 65(5), 10-1128. [PMID: PMC8092903]

Year: 2020

• Gaurav, A., Kothari, A., Omar., B, and Pathania, R. "Assessment of polymyxin B-doxycycline combination against Pseudomonas aeruginosa in in vitro and in a mouse acute pneumonia model."; International Journal of Antimicrobial Agents (2020): 106022. [PMID: 32439481]

• Uppalapati, S.R., Sett, A. and Pathania, R. "The outer membrane proteins OmpA, CarO and OprD of Acinetobacter baumannii confer a two-pronged defense in facilitating its success as a potent human pathogen". Frontiers in microbiology, (2020) 11. [PMID: PMC7573547]

Year: 2019

• Bhando, T., Bhattacharyya, T., Gaurav, A., Akhter, J., Saini, M., Gupta, V.K., Srivastava, S.K., Sen, H., Navani, N.K., Gupta, V. and Biswas, D., Pathania, R. . "Antibacterial properties and in vivo efficacy of a novel nitrofuran, IITR06144, against MDR pathogens". Journal of Antimicrobial Chemotherapy (2019). [PMID: 31665357] 

• Tahlan, S., Kumar, S., Ramasamy, K., Lim, S.M., Shah, S.A.A., Mani, V., Pathania, R. and Narasimhan, B., (2019). "Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents". BMC Chemistry, 13(1), p.50. [PMID: PMC6661758]

• Sharma, A., Gupta, V.K. and Pathania, R. "Efflux pump inhibitors for bacterial pathogens: From bench to bedside". The Indian Journal of Medical Research, (2019) 149(2), p.129. [PMID: PMC6563736]

• Ghosh, T., Srivastava, S.K., Gaurav, A., Kumar, A., Kumar, P., Yadav, A.S., Pathania, R. and Navani, N.K. "A Combination of Linalool, Vitamin C, and Copper Synergistically Triggers Reactive Oxygen Species and DNA Damage and Inhibits Salmonella enterica subsp. enterica Serovar Typhi and Vibrio fluvialis". Applied Environmental Microbiology, (2019), 85(4), pp.e02487-18. [PMID: PMC6365828]

Year: 2018

• Sharma, A., Dubey, V., Sharma, R., Devnath, K., Gupta, V.K., Akhter, J., Bhando, T., Verma, A., Ambatipudi, K.S., Sarkar, M., Pathania, R. "The unusual glycine rich C-terminus of the Acinetobacter baumannii RNA chaperone Hfq plays an important role in bacterial physiology." Journal of Biological Chemistry, (2018) 293, 13377-13388 [PMID: 30002121]

• Gupta, V. K., Gaur, R., Sharma, A., Akther, J., Saini, M., Bhakuni, R. S., & Pathania, R. (2018). "A novel bi-functional chalcone inhibits multi-drug resistant Staphylococcus aureus and potentiates the activity of fluoroquinolones". Bioorganic Chemistry. j.bioorg.2018.10.024. [PMID: 30380450]

Year: 2017

• Sharma, A., Sharma, R., Bhattacharyya, T., Bhando, T., Pathania, R. (2017). "Fosfomycin resistance in Acinetobacter baumannii is mediated by efflux through a major facilitator superfamily (MFS) transporter—AbaF". Journal of Antimicrobial Chemotherapy, 72, 68–74. [PMID: 27650185]

• Bhattacharyya, T., Sharma, A., Akhter, J., & Pathania, R. (2017). "The small molecule IITR08027 restores the antibacterial activity of fluoroquinolones against multidrug-resistant Acinetobacter baumannii by efflux inhibition". International journal of antimicrobial agents, 50(2), 219-226. [PMID: 28533185]

Year: 2016

• Srivastava, S. K., Iyer, V. R., Ghosh, T., Lambadi, P. R., Pathania, R., & Navani, N. K. (2016). "Isolation of a non-genomic origin fluoroquinolone responsive regulatory element using a combinatorial bioengineering approach". Nucleic acids research. 44(5), 2451-2461. [PMID: 26837578]

Year: 2015

• Lambadi, P. R., Sharma, T. K., Kumar, P., Vasnani, P., Thalluri, S. M., Bisht, N., Pathania, R. and Navani, N. K. (2015). "Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control". International journal of nanomedicine. 10, 2155. [PMID: 25834431]

Year: 2014

• Srivastava, S. K., Lambadi, P. R., Ghosh, T., Pathania, R., & Navani, N. K. (2014). "Genetic regulation of spy gene expression in Escherichia coli in the presence of protein unfolding agent ethanol". Gene. 548(1), 142-148. [PUBMED Link]

• Sharma, R., Arya, S., Patil, S. D., Sharma, A., Jain, P. K., Navani, N. K., & Pathania, R. (2014). "Identification of novel regulatory small RNAs in Acinetobacter baumannii". PloS one. 9(4), e93833. [PUBMED Link]

Year: 2013

• Patil, S.D., Sharma, R., Srivastava, S.K., Navani, N.K. and Pathania, R. (2013). "Downregulation of yidC in Escherichia coli by antisense RNA expression results in sensitization to antibacterial essential oils eugenol and carvacrol". PLoS ONE. 8(3), e57370. [PUBMED Link]

• Ghosh, I., Patil, S.D., Sharma, T.K., Srivastava, S.K., Pathania, R. and Navani, N.K. (2013). "Synergistic action of cinnamaldehyde with silver nanoparticles against spore-forming bacteria; a case for judicious use of silver nanoparticles for antibacterial applications". International Journal of Nanomedicine.8, 4721-4731. [PUBMED Link]

Year: 2012

• Iyer, V.R., Sharma, R., Pathania, R. and Navani, N.K. (2012). "Small RNAs of Pathogenic Bacteria: Not Small Enough to be overlooked for Therapeutics". Molecular and Cellular Pharmacology .4(1), 17-30. [Link]

• Sharma, T.K., Sapra, M., Chopra, A., Sharma, R., Patil, S.D., Pathania, R. and Navani, N.K. (2012). "Interaction of bacteriocin-capped silver nanoparticles with food pathogens and their antibacterial effect". International Journal of Green Nanotechnology. 4(2), 93-110. [Link]

• Sharma, T.K., Chopra, A., Sapra, M., Kumawat, D., Patil, S.D., Pathania, R. and Navani, N.K. (2012). "Green Synthesis and Antimicrobial Potential of Silver Nanoparticles". International Journal of Green Nanotechnology .4(1), 1-16. [Link]

• Bhatia, A., Ali, M., Jitendra, S., Madan, S., Pathania, R., Ahmed,N., Kazmi. A.A. (2012). "Microbial diversity during rotary drum and windrow pile composting". Journal of Basic Microbiology .52, 5–15. [PUBMED Link]

• Bhatia, A., Madan, S., Jitendra, S., Ali, M., Pathania, R., Kazmi, A, A. (2012). "Diversity of bacterial isolates during full scale rotary drum composting". Waste Management .33, 1595- 1601. [PUBMED Link]

Year: 2009

• Pathania, R., Zlitni, S., Barker, C., Das, R., Gerritsma, D., Lebert, J., Awuah, E., Melacini, G., Capretta, F. and Brown, E. (2009). "Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting". Nature Chemical Biology. 5, 849-856. [PUBMED Link]

• Mok, W., Navani, N.K., Barker,C., Sawchyn,B., Gu, J., Pathania, R.,  Zhu, R., Brown, E. and  Yingfu Li. (2009). "Identification of a toxic peptide through bidirectional expression of small RNAs". Chembiochem .10, 238-241. [PUBMED Link]

Year: 2008

• Pathania, R. and Brown, E.D (2008). "Small and lethal: searching for new antibacterial compounds with novel modes of action". Biochemistry and Cell Biology .86(2)111-5. [PUBMED Link]

Year: 2002

• Pathania, R., Navani,N.K., Rajmohan, G. and Dikshit, KL. (2002). "Mycobacterium tuberculosis hemoglobin HbO associates with membranes and stimulates cellular respiration of recombinant E.coli". Journal of Biological Chemistry .277(18), 15293-15302. [PUBMED Link]

• Pathania, R., Navani,N.K., Gardner, A.M., Gardner, P.M. and Dikshit, KL. (2002). "Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis hemoglobin, HbN, in E. coli". Molecular Microbiology. 45(5):1303-14 [PUBMED Link]

• Ramandeep, Pathania, R., Sharma, V., Mande, S.C., & Dikshit, K.L. (2002). "Chimeric Vitreoscilla hemoglobin (VHb) carrying flavoreductase domain relieves nitrosative stress in E. coli: new insight into the functional role of VHb". Applied and Environmental Microbiology .68, 152-160. [PUBMED Link] 

Books

Year: 2019

• Gaurav A., Sharma A., Pathania R. (2019) Efflux Mediated Co-resistance. In: Mandal S., Paul D. (eds) Bacterial Adaptation to Co-resistance. Springer, Singapore.

• Bhando T., Dubey V., Pathania R. (2019) Biofilms in Antimicrobial Activity and Drug Resistance. In: Mandal S., Paul D. (eds) Bacterial Adaptation to Co-resistance. Springer, Singapore

• Dubey, V., Arya, S., Sen, D., Sharma, A. and Pathania, R., (2019). Computational Prediction of sRNA in Acinetobacter baumannii. In Acinetobacter baumannii (pp. 307-320). Humana Press, New York, NY.

Year: 2013

• Aradhana Chopra, Tarun   Kumar Sharma, Ranjana Pathania and  Naveen Kumar Navani. (2013). Aptamer – nanoparticles based nanobiosensor for bacterial detection. Studium press LLC, USA.

• Mahak Sapra, Tarun   Kumar Sharma, Piyush Kumar, Ranjana Pathania and Naveen Kumar Navani. (2013) Nanoparticles based optical detection of xenobiotics small molecules. Studium press LLC, USA.

Year: 2010

• Himanshu Joshi, Babita Sinha, Ranjana Pathania and P.K. Ghosh. (2010) Knowledge Sharing and Intellectual Property Management - Status and Strategies. LAP Lambert Academic Publishing. ISBN 978-3-8383-2070-0, 244 Pages.

Year: 2004

• Ranjana Pathania, Govindan Rajamohan and Kanak L. Dikshit. (2004). Novel hemoglobis of M. Tuberculosis: Role in pathogenicity and cellular metabolism. In “Deep Roots Open Skies: New Biology in India”. Eds S.K.Basu, K.K.Batra and D.M. Salunake. pp. 163-166, 2004

Patents

Granted

Methods and composition for identification of novel anti-persister activity of GRAS compounds (2019). R. Pathania, Timsy Bhando, Ananth Casius. Indian Patent Office. (Patent No. 424983 granted on 14/03/2023).

E. D. Brown, R. Pathania and F. Capretta. A novel lead series of antibacterial compounds with activity against Gram-negative bacteria. (2008). WO/2008/025152.

E. D. Brown, X. Li, G. Wright, J. Cechetto, M. Juran, R. Hartlen and R. Pathania. Method of inhibiting dihydrofolate reductase; screening assay for the identification of novel therapeutics and their cellular targets. (2005).US 7524644 

G. Rajamohan, M. Dahiya, R. Pathania and K.L. Dikshit. Method for oxygen regulated production of recombinant staphylokinase. (2005). US 20050019862

Filed

A therapeutic composition for the treatment of resistant and Persistent Bacterial Infections. R. Pathania, Timsy Bhando. Indian Patent Office. (Patent application No. 201911043932).

“A composition comprising of 2-aminoperimidine and polymyxin B for the treatment of multidrug-resistant bacterial topical infections”. R. Pathania, Mahak Saini (Date of filing: 09/06/2022 Application no. 202211033140)